She was a younger sister of Anne of York, Duchess of Exeter, Edward IV of England and Edmund, Earl of Rutland. She was an older sister of Margaret of York, George Plantagenet, 1st Duke of Clarence and Richard III of England.
Her eldest son, John de la Pole, 1st Earl of Lincoln (c. 1462-16 June 1487). was designated heir to his maternal uncle Richard III. Married to Lady Margaret FitzAlan and had a son Edward de la Pole, who died young.
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